The LCH IV study seeks to tailor treatment based on features at presentation and on response to treatment based on seven strata due to the complexity of the disease presentations and outcomes.
Patients will be enrolled into a first line treatment and of those patients depending on diagnosis with be put into two groups. Patients failing first line treatment with be eligible for the other interventional strata depending on their presentation and response to treatment.
Basic Eligibility Criteria:
Inclusion criteria includes definitive diagnosis of Langerhans cell histiocytosis, age of less than eighteen years at time of definitive diagnosis, have met the inclusion criteria for the respective stratum, signed written informed consent. Exclusion criteria is stratum dependent.
Phoenix Children’s Hospital